Expression of Th1/Th2 chemokines and their receptors in the lesions of bullous pemphigoid
- VernacularTitle:大疱性类天疱疮皮损中Th1/Th2趋化因子及其受体的表达
- Author:
Shiling GENG
;
Shijun SHAN
;
Jian WU
;
Zhihua WANG
;
Ting XIAO
;
Xinghua GAO
;
Hongduo CHEN
- Publication Type:Journal Article
- Keywords:
Bullous Pemphigoid;
CXCL9;
CXCL10;
CXCL11;
CCL22;
CXCR3;
CCR4
- From:
Chinese Journal of Immunology
2010;26(3):270-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of Th1 chemokine CXCL9,CXCL10,CXCL11,Th2 chemokine CCL22 and their receptors in the lesions of bullous pemphigoid (BP).Methods:Immunohistochemical assay was performed to detect the expression of CXCL9,CXCL10,CXCL11,CCL22 and their receptors CXCR3 and CCR4 in BP lesions and normal control skin.Results:CXCL9,CXCL10,CXCL11,CCL22,CXCR3 and CCR4 were overexpressed in BP lesions than those in normal control skin (P＜0.01).The positive rates of CXCL9,CXCL10,CXCL11 and CXCR3 in BP lesions were 50%(15/30),46.7%(14/30),46.7%(14/30) and 53.3%(16/30),respectively.The positive rates of CCL22 and CCR4 were 66.7% (20/30) and 56.7% (17/30).Conclusion:The overexpression of Th1 chemokine CXCL9,CXCL10,CXCL11,Th2 chemokine CCL22 and their receptors may play important roles in the pathogenesis of BP.
