Toll-like receptor 4 and damage of central nervous system
- VernacularTitle:TLR4与中枢神经系统损伤
- Author:
Cuizhi GU
;
Feiling FENG
- Publication Type:Journal Article
- Keywords:
Receptors,Toll-like;
Central nervous system;
Damage
- From:
Chinese Journal of Pathophysiology
2010;26(3):608-612
- CountryChina
- Language:Chinese
-
Abstract:
As a receptor mediating the transmembrane signal transduction in the innate immunity, Toll-like receptor 4 (TLR4) is a bridge between innate immunity and required immunity, and plays an important role when signal-transducing of some cells are activated. Recent reports show that TLR4 expresses in the different glial cells and strongly links to the innate immune activation and inflammatory response in the central nervous system (CNS). TLR4 plays a key role in the processes of brain damage by infection of the CNS, stroke, cerebral hemorrhage and trauma. In this review, we concentrate on recent findings regarding the progress of function and mechanism of TLR4 in the processes of the CNS damage in various diseases.
