The study on the correlation of C1773T polymorphism of LDL receptor gene (LDLR) with cerebral hemorrhage and its impact on the levels of serum lipids in Chinese
- VernacularTitle:低密度脂蛋白受体基因C1773T多态性与长沙汉族人群脑出血的相关性研究及其对血脂水平的影响
- Author:
Yi ZENG
;
Le ZHANG
;
Mingming MA
;
Qidong YANG
;
Zhongyang HU
;
Baoqiong LIU
;
Jian XIA
;
Yunhai LIU
;
Hongwei XU
;
Zhiping HU
;
Hongxing WANG
- Publication Type:Journal Article
- Keywords:
LDLR;
Gene polymorphism;
Cerebral hemorrhage;
Serum lipid levels
- From:
Chinese Journal of Nervous and Mental Diseases
2010;36(3):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between C1773T polymorphism of LDL receptor gene (LDLR) and cerebral hemorrhage and the impact of C1773T polymorphism of LDLR on the levels of serum lipids in Chinese Han in Changsha, Hunan province. Methods Two hundred seventy-three cerebral hemorrhage patients and 140 normal controls were recruited in the present study. The C1773T polymorphism of LDLR was analyzed by SNaPshot and direct DNA sequencing. The triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) levels were examined using oxidase method. Results The CC, CT and TT genotype frequencies of LDLR polymorphism were 0.703/0.278/0.019、0.707/0.250/0.043 and the allele C and T frequencies of LDLR polymorphism in the cerebral hemorrhage group and the control group were 0.842/0.158,0.832/0.168 respectively. The differences in genotype and allele frequencies of LDLR polymorphism were no significant between cerebral hemorrhage group and the control group (P>0.05). There were no significant differences in the levels of lipids among the CC, CT and TT genotype in either cerebral hemorrhage group or the control group (P＞0.05). Conclusions The LDLR-C1773T polymorphism may not be associated with cerebral hemorrhage nor be related to hyperlipemia in Chinese Han in Changsha.
