Advancement in the pharmacogenetics of antiplatelet drugs
- VernacularTitle:抗血小板药物的遗传药理学研究进展
- Author:
Lan FAN
;
Wei ZHANG
;
Honghao ZHOU
- Publication Type:Journal Article
- Keywords:
antiplatelet drugs;
pharmacogenetics;
single nucleotide polymorphism;
aspirin;
clopidogrel;
prasugel
- From:
Chinese Pharmacological Bulletin
2010;26(4):421-424
- CountryChina
- Language:Chinese
-
Abstract:
Nowadays,cerebrovascular disease is one of the main causes of human death.Activation and aggregation of the platelet play core roles in the development of cerebrovascular diseases.A lot of clinical applications have showed that there are great interindividual differences in the response to antiplatelet drugs,and many patients have developed drug resistances.Pharmacogenetic studies have revealed that genetics is one of the key factors resulting in the interindividual differences of the response to antiplatelet drugs.In this overview,the newest advancement in pharmacogenetics is summarized with respect to the antiplatelet drugs.
