Angiopoietin-like protein 3 and adiponectin levels in patients with metabolic syndrome
10.3969/j.issn.1672-7347.2010.03.003
- VernacularTitle:代谢综合征患者血清脂联素和血管生成素样蛋白3水平的变化及意义
- Author:
Wanbei GUO
;
Zhihong CHE
;
Aimin XU
;
Zhiguang ZHOU
- Publication Type:Journal Article
- Keywords:
metabolic syndrome;
angiopoietin-like protein 3;
adiponectin
- From:
Journal of Central South University(Medical Sciences)
2010;35(3):203-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum angiopoietin-like protein 3 (Angptl3) and adiponectin levels in patients with metabolic syndrome (MS) in order to understand their association with the MS. Methods Serum Angptl3 and adiponectin levels were measured by sandwich ELISA in a group of 111 patients with MS and 152 normal controls. Results Serum adiponectin was lower in the MS patients than in the control subjects [4.22(1.01-23.29) μg/mL vs. 5.41(0.97-22.27) μg/mL, P＜0.05]. With regard to serum Angptl3, there was no significant difference between the 2 groups(P＞0.05). Serum adiponectin was correlated to Angptl3 and high density lipoprotein-cholesterol (HDL-C)(P＜0.001) and negatively correlated to body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), triglyceride (TG), fasting plasma glucose (FBG), fasting insulin (FINS) and homeostatic model assessment method-insulin resistance (HOMA-IR) (P＜0.001). Serum Angptl3 was positively correlated with adiponectin (P＜0.001). Serum adiponectin was found to be independently positive determinant for Angptl3 concentrations (b′=0.256, P＜0.001). Adiponectin was inversely correlated with TG and HOMA-IR (b′=-0.234, -0.145, P＜0.001). Conclusion Adiponectin is decreased in MS patients and may be correlated to Angptl3.
