Experimental Study of First-Pass Myocardial Perfusion MRI on Pig Myocardial Infarction Model
10.3969/j.issn.1002-1671.2010.01.030
- VernacularTitle:猪心梗模型MRI心肌首过灌注实验研究
- Author:
Xinxiang ZHAO
;
Dakuan YANG
;
Shuguang YUAN
;
Xuantao YANG
;
Xinhuan YANG
;
Baozhen PAN
;
Jiancheng HAO
;
Duo XU
;
Zheng XIAO
- Publication Type:Journal Article
- Keywords:
MRI;
ischemic myocardium;
pig,experiment
- From:
Journal of Practical Radiology
2010;26(1):106-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the ischemic myocardial perfusion and viability.Methods Ten successful pigs with myocardial infarction model underwent MRI first-pass myocardial perfusion examinations preoperatively and 24 hours,72 hours and one week postoperation.After MRI examinations,the experimental pigs were executed and the samples underwent TTC staining and pathological examination.Results The preoperative myocardial perfusion in the all of the 10 pigs was nomal,but there were myocardial perfusion decrease and defects in 8 experimental pigs after operation,the perfusion curves in the area with perfusion defects had no obvious peak,but there was gradual increase in the end of the performance.The perfusion peak of the area with perfusion decrease was lower than that of normal inferior and lateral myocardial wall(P＜0.05) and the peak perfusion time was delayed compared with that of normal inferior and lateral myocardial wall (P＜0.05).There was myocardial necrosis in the perfusion defects areas that was certified by TTC staining and pathological examination.The intersititial edema and myocardial degeneration could be seen in the perfusion reduced areas.Conclusion MRI fist-pass myocardial perfusion imaging combined with perfusion curve analysis can evaluate the perfusion changes of the regional myocardial microcirculation.
