Effect of ginsenoside Rg1 on gut injury following intestinal ischemia reperfusion in rats
- VernacularTitle:人参皂苷Rg1对大鼠肠缺血/再灌注损伤的影响
- Author:
Qian LI
;
Yanmin ZHANG
;
Yue GUAN
;
Huijie MA
;
Lu GAO
;
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
ginsenoside Rg1;
small intestines;
ischemia-reperfusion;
tumor necrosis factor α;
interleukin-6;
malondialdehyde;
superoxide dismutase
- From:
Chinese Pharmacological Bulletin
2010;26(3):358-361
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of ginsenoside Rg1 on gut injury following intestinal ischemia reperfusion in rats and the possible mechanism.Methods By using rat model of intestinal I/R injury, 30 male SD rats were randomly divided into 3 groups(n =10 in each group):sham-operation group, I/R group(control group)and ginsenoside Rg1 group(treatment group).The contents of tumor necrosis factor α(TNF-α), interleukin-6(IL-6), malondialdehyde(MDA), the activity of superoxide dismutase(SOD)in intestinal mucosa were measured respectively.Chiu's count was used to assess the changes in intestinal pathological morphology.Results TNF-α, IL-6, MDA contents and the intestinal injury score in control group were significantly increased compared to those in sham-operation group, while SOD contents in control group were significantly decreased compared to sham-operation group.Inversely, TNF-α, IL-6, MDA contents and the intestinal injury score in treatment group were significantly decreased compared to those in control group, while SOD contents in treatment group were significantly increased compared to control group.Conclusion Pretreatment with ginsenoside Rg1 has protective effect on intestinal ischemia-reperfusion injury in rats, which may be attributed to decreased contents of TNF-α, IL-6, MDA and increased levels of SOD.
