Effect of polygonum cuspidatum and hawthorn on anti-atherosclerosis unstable plaque
10.3969/j.issn.1000-4718.2010.04.003
- VernacularTitle:虎杖配伍山楂抗动脉粥样硬化易损斑块病变的机制研究
- Author:
Guangjuan ZHENG
;
Ying ZHU
;
Ting WANG
- Publication Type:Journal Article
- Keywords:
Polygonum cuspidatum and hawthorn;
Apolipoprotein E gene knockout mice;
Atherosclerosis;
NF-kappa B;
High-sensitivity C-reactive protein
- From:
Chinese Journal of Pathophysiology
2010;26(4):635-639
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of detoxifying herbs polygonum cuspidatum, and hawthorn, herb of promoting blood flow, on pathologic morphology and inflammatory factors in apolipoprotein E gene knockout mice, in order to approach the possible regulatory mechanism of polygonum cuspidatum and hawthorn for treating artherosclerosis (AS) unstable plaque. METHODS: The animals were divided into 7 groups (12 mice in every group). The ApoE (-/-) mice fed with high fat diet were divided into polygonum cuspidatum group, hawthorn group, polygonum cuspidatum + hawthorn group, Xuezhikang group and high fat diet model group. Moreover, ApoE (-/-) mice fed with normal diet (normal diet group) and C57BL/6J mice fed with normal diet (normal control group) were set up. After intragastric administration for 17 weeks, serum hs-CRP was detected, aorta structure was observed under light microscope and NF-κB protein expression was determined by immunohistochemistry. RESULTS: The pathological change of AS in aorta in all groups fed with high fat diet and normal diet group were observed with different degree. The changes of aortic lesion in all treatment groups were reduced. The levels of NF-κB and hs-CRP in high fat diet group were significant higher than those in normal control group and normal diet group. Serum NF-κB and hs-CRP levels decreased in every treatment group, which were significant different from those in high fat diet model group (P<0.01). Among them, the changes in polygonum cuspidatum and hawthorn groups were the best. CONCLUSION: Chinese herbs of polygonum cuspidatum and hawthorn reduce inflammatory factors NF-κB and hs-CRP expression and play a role in anti-AS formation.
