Protective effects of auricularia auricular polysaccharide on chronic cerebral ischemia injury in rats
10.3969/j.issn.1000-4718.2010.04.019
- VernacularTitle:黑木耳多糖对抗大鼠慢性缺血性脑损伤
- Author:
Shunfei LU
;
Lina SUN
;
Jia SHEN
;
Fang SU
;
Huiping WANG
;
Zhiguo YE
;
Tingmei YE
;
Qiang XIA
- Publication Type:Journal Article
- Keywords:
Auricularia auricular polysaccharide;
Brain ischemia;
Morris water maze;
Malondialdehyde;
Superoxide dismutase
- From:
Chinese Journal of Pathophysiology
2010;26(4):721-724
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of auricularia auricular polysaccharide (AAP) on chronic cerebral ischemia injury in rats. METHODS: The chronic cerebral ischemia mode1 was made by permanent middle cerebral artery occlusion (MCAO) on the right side. AAP at different doses (50 mg/kg and 100 mg/kg) was intragastrically administered at the onset of ischemia and in the following days after operation, once a day for 4 weeks. After 4 weeks of MCAO, Morris water maze test was introduced to examine the learning and memory functions. Nissl staining was performed to detect the survival neurons in hippocampal slices. Level of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in brain tissue were measured. RESULTS: Rats treated with AAP showed a shorter escaping latency in spacial navigation test because the AAP treated rats spent less time to find the platform in spatial probe test. More survival neurons in hippocampal slices were observed from AAP treated rats. Also, the MDA level in brain tissue was reduced and SOD activity in brain tissue was increased in the AAP treated rats with MCAO. CONCLUSION: AAP protects rats from chronic brain ischemic injury, in which its anti-oxidative effect might be involved.
