The Relationship of Loss of P16 Expression with Biological Behaviors and Prognosis of Gastrointestinal Stromal Tumors

VernacularTitle:P16表达缺失与胃肠道间质瘤生物学行为及预后关系
Author: Zhankao ZHAO ; Zhongmin JIANG ; Tao HE ; Wenjuan JIA ; Baocun SUN
Publication Type:Journal Article
Keywords: Gastrointestinal stromal tumors; P16; Immunohistochemistry; Reverse transcription polymerase chain teaction
From: Chinese Journal of Clinical Oncology 2010;37(5):257-259
CountryChina
Language:Chinese
Abstract: Objective: To investigate the relationship of loss of P16 expression with biologlical behaviors and prognosis of gastrointestinal stromal tumors(GISTs). Methods: The expression of P16 protein and mRNA was detected in GISTs tissues by immunohistochemistry,Western blot and RT-PCR.The prognosis was evaluated through follow up. Results: The expression rates of P16 protein and mRNA in GISTs were 53.8%(21/39，Frozen tissue)，51.3%(20/39，Frozen tissues)and 51.4%(37/72，Paraffin-embedded tissues)，respectively.The expression of P16 was significantly different among GISTs of different aggressive risk(P<0.05).With the incease of aggressive risk，the expression of P16 was deceased.The expression of P16 was negtively correlated with Ki-67 and patient survival(P<0.05). Conclusion: The loss of P16 expression has a positive correlation with the infiltration and progression of GIST.Detection of P16 protein and mRNA is helpful for the evalutaion of biological behaviors and prognosis of gastrointestinal stromal tumors.