Effect of Concurrent Chemoradiotherapy on Patients'Serum CD44v6 and VEGF Levels and Its Clinical Significance
10.3969/j.issn.1000-8179.2010.05.006
- VernacularTitle:不能手术的非小细胞肺癌同步放化疗对血清CD44v6和VEGF表达水平的影响及其临床意义
- Author:
Xiaotao ZHANG
;
Zhen ZHANG
;
Shuhong HAN
;
Xuezhen MA
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
CD44v6;
Vascular endothelial growth factor;
Concurrent chemoradiotherapy;
Serum
- From:
Chinese Journal of Clinical Oncology
2010;37(5):260-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the changes in serum CD44v6/v EGF(sCD44v6/sVEGF)levels after concurrent chemoradiotherapy in patients with inoperable non-small cell lung cancer(NSCLC)patients and to analyze the correlation of serum markers with patients'prognosis. Methods: The sCD44v6/v EGF levels were detected by ELISA in 50 inoperable NSCLC patients before and after concurrent chemorediotherapy. Results: The sCD44v6 and sVEGF levels before treatment was significantly higher than that in the control group.The pre-treatment sVEGF level was closely related to cTNM stage.metastasis,cell differentiation and primary tumor size,but was not correlated with histological classification,lymph node status,age or gender.The pre-treatment sCD44v6 level was closely correlated with cTNM stage,metastasis,cell differentiation,and primary tumor size,but was not correlated with histological classification,age or gender.Patients'sCD44v6 before treatment(570.89±63.30 ng/L)was significantly higher than that after treatment(281.44±74.28 ng/L).Patients'sVEGF before treatment(241.09±85.96 ng/L)was significantly higher than that after treatment(133.64±67.69 ng/L).PD patients had the highest level of sCD44v6 and sVEGF and CR patients had the lowest sCD44v6 and sVEGF level.The sVEGF level was highly correlated with sCD44v6(r=0.291,P<0.05).Conclusion:The sCD44v6 and sVEGF levels might be helpful for evaluation of the biological behavior and prognosis of NSCLC.
