Influence of Glutamate on the Circling Movement In the Unilateral Substantia Nigra-lesioned Rats.
- Author:
Myeong Il HAN
1
;
Young Chul CHUNG
;
Hong Bai EUN
Author Information
1. Department of Neuropsychiatry, School of Medicine, Chonbuk National University, Chonju, Korea.
- Publication Type:Original Article
- Keywords:
Dopamine;
Glutamate;
Bicuculline;
Substantia nigra Striatum
- MeSH:
Animals;
Apomorphine;
Bicuculline;
Dopamine;
GABA Antagonists;
gamma-Aminobutyric Acid;
Glutamic Acid*;
Rats*;
Substantia Nigra
- From:Journal of Korean Neuropsychiatric Association
1997;36(5):919-926
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The aim of this study was to examine the effects of various concentrations of glutamate(10(-8), 10(-6) and 10(-4) M) on the circling movement induced by apomorphine in the unilateral substantia nigra-lesioned rats. Subcutaneous apomorphine(0.1 mg/kg) elicited contralateral circling movement(641.7+/-163.9/hr), Glutamate(10(-6)-10(-4) M) significantly reduced the numbers of apomorphine-induced circling movement. This reducing effect of glutamate was antagonized and/or reversed by 10(-7) M GABA antagonist bicuculline. These results suggest that glutamate reduces circling movement induced by apomorphine and this reducing effect of glutamate may be mediated by increased GABA concentration in striatum and substantia nigra.
