Prostaglandin E receptors in regulation of blood pressure
- VernacularTitle:前列腺素E受体与血压调节
- Author:
Yifei MIAO
;
Jihong KANG
;
Jichun YANG
;
Youfei GUAN
- Publication Type:Journal Article
- Keywords:
prostaglandins;
prostaglandin E_2;
prostaglandin E receptors;
blood pressure;
salt-sensitive hypertension;
myocardial hypertrophy
- From:
Chinese Pharmacological Bulletin
2010;26(4):424-427
- CountryChina
- Language:Chinese
-
Abstract:
Prostaglandin E_2(PGE_2)is one of the major metabolic products of arachidonic acid.PGE_2 plays important roles in various important physiological processes by binding to its G protein-coupled receptors designated EP1,EP2,EP3,and EP4,respectively.EP receptors are highly expressed in the kidney and cardiovascular system,and PGE2-mediated activation of EP receptors plays important roles in the regulation of blood pressure.The abnormal expression of EP receptors in the kidney and cardiovascular system is associated with some blood pressure disease such as salt-sensitive hypertension,renal hypertension,and myocardial hypertrophy.
