Clinical observation of nicorandil in treatment of 85 patients with angina pectoris
10.3760/cma.j.issn.1008-6706.2011.04.014
- VernacularTitle:尼可地尔治疗心绞痛80例临床观察
- Author:
Yuehong CHEN
;
Bingzhong CHEN
;
Hai LIN
- Publication Type:Journal Article
- Keywords:
Nicorandil;
Angina pectoris;
Therapeutic effect
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(4):464-465
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the therapeutic effect of nicorandil in treatment of angina pectoris. Methods155 cases of angina pectoris patients were randomly divided into the therapeutic group(85 cases)and control group(70 cases),both of which took normal doses of aspirin vitamin C effervescent tablets 0.1g/day,clopidogrel 50mg/day,elantan 50mg/day and simvastatin 40mg/day,where hypertensions or diabetics were given blood pressure and sugar control and heart failure patients were given proper diuretic therapy and other methods to release heart Ioad.Patients in the therapeutic group were additionally given 5 mg nicorandil,3 times/day.The two groups were both given one period of treatment about one month. ResultsIn therapeutic group,32 cases had significant therapeutic effectiveness,34 cases had effectiveness and 14 cases had no effectiveness with a total effective rate of 82.5%.In the control group,23 cases had significant therapeutic effectiveness,28 cases had effectiveness and 24 cases had no effectiveness with a total effective rate of 67.0%.The comparative difference of the total effectiveness of the twogroups had statistical significance(x2 =4.40,P＜0.05).No other significant adverse reaction was found except several cases of light dizzy in the two groups. ConclusionNicorandil has good therapeutic effective in treatment of angina pectoris and no significant adverse reaction.
