TSPO:new nomenclature for the peripheral benzodiazepine receptor and its role in the neuropsycopharmacology
- VernacularTitle:TSPO:外周苯二氮卓受体的新命名及其在中枢神经系统中的作用
- Author:
Yue ZHAO
;
Pingping ZUO
;
Senyang LANG
- Publication Type:Journal Article
- Keywords:
PBR;
Translocator protein (18 ku,TSPO);
neuropsycopharmacology;
neurodegenerative disease;
mental disorder
- From:
Chinese Pharmacological Bulletin
2010;26(4):432-435
- CountryChina
- Language:Chinese
-
Abstract:
The early characterization of the diazepam-binding sites outside the brain led to their assignment as peripheralbenzodiazepine receptors, or PBRs, to distinguish them from the central benzodiazepine receptor.Although PBR is a widely used and accepted name in the scientific community,recent data regarding the structure and molecular function of this protein increasingly support renaming it to represent more accurately its subcellular role (or roles) and putative tissue-specific function (or functions). Translocator protein (18 ku,TSPO), is proposed as a new name, regardless of the subcellular localization of the protein. This review deals with the pharmacological, structural and molecular characterization of the PBR and its role in the neuropshcopharmacology.
