The Effect of Cyproheptadine Treatment in Neuroleptic Induced Akathisia.
- Author:
Dong Seon CHUNG
1
;
In Joon PARK
;
Young Joon KWON
;
Hee Yeon JUNG
;
Sun Ho HAN
Author Information
1. Department of Neuropsychiatry, Chu-an Hospital, Soonchunhyang University, College of Medicine, Chunan, Korea.
- Publication Type:Original Article
- Keywords:
Akathisia;
Cyproheptadine
- MeSH:
Cyproheptadine*;
Depression;
Humans;
Psychomotor Agitation*;
Psychotic Disorders
- From:Journal of Korean Neuropsychiatric Association
1997;36(5):935-941
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Neuroleptic Induced Akathisia(NIA) often occurs in neuroleptic treated patients. Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic induced akathisia. METHOD: In an open trial 21 neuroleptic-treated patients with akathisia were administrated Cyproheptadine(16mg/day) over 4 days. Assessment of akathisia was evaluated using Barnes' rating scale(BAS) for neuroleptic induced akathisia. The degree of depression and psychosis were assessed by brief psychiatric rating scale(BFRS) and Hamilton rating scale for depression(HAM-D). RESULT: Most patients(20 of 21) with neuroleptic induced akathisia(NIA) showed improvement under the treatment of cyproheptadine. There was no aggravation of psychosis or depression during the treatment. Symptoms of akathisia aggravated when cyproheptadine was discontinued. CONCLUSION: Cyproheptadine may be useful in the treatment of neuroleptic induced akathisia(NIA).
