The relationship between glyoxalaseⅠand diabetic complications
- VernacularTitle:乙二醛酶Ⅰ与糖尿病并发症的关系
- Author:
Zhi LI
;
Shijun YAN
;
Sitong WANG
;
Jun SHENG
;
Wensheng ZHANG
- Publication Type:Journal Article
- Keywords:
glyoxalaseⅠ;
methylglyoxal;
α-oxoaldehydes;
AGEs;
diabetic complications;
regulatory net
- From:
Chinese Pharmacological Bulletin
2010;26(4):428-431
- CountryChina
- Language:Chinese
-
Abstract:
GlyoxalaseⅠthat presents in all human tissues detoxifies α-oxoaldehydes and prevents the formation of advanced glycation end products(AGEs).AGEs and their main precursor namely methylglyoxal(MG)produce cytotoxicity and have extensive relationship with diabetic complications.Therefore,to elevate glyoxalaseⅠactivity may be a new path to release such complications.
