Application of medical polymer carrier materials to anticancer drugs
10.3969/j.issn.1673-8225.2010.08.030
- VernacularTitle:医用高分子载体材料在抗肿瘤药物中的应用
- Author:
Xi WANG
;
Jing XUE
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2010;14(8):1455-1458
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To introduce the type and biological properties of medical polymer vehicle materials, and to evaluate its application in anticancer drugs. METHODS: A computer-based on-line research was performed in China Journal Full-text Database and Pubmed database published from 1990 to 2009. The key words were "polymer, anticancer drug, carrier". Articles concerning biological properties of medical polymer vehicle materials and its application in anticancer drugs were included. Meta analysis and repetitive studies were excluded. RESULTS: Quality of articles was assessed, and a total of 24 articles were included. Biological properties of medical polymer vehicle materials and its application in anticancer drugs were summarized. Medical polymer vehicle materials are novel technique with the development of pharmacological study, biomaterial study and clinical medicine. Good biocompatibility, biodegradability, regulation of degradation rate and good workability of polymer materials provided convenience and possibility for innovation of pharmaceutical preparation. Structure of drug carrier material, elevation of drug-loading efficiency, in vivo distribution, biodegradation function and effects of degradation product on bodies deserved further investigations. The study focus of anticancer drug high polymer carrier lies in the search of carrier materials with strong choice and good outcomes. CONCLUSION: Medical polymer carrier materials can control drug release speed by dosage form changes, which induced a stable drug concentration in vivo. The medical polymer carrier materials also can send drugs to a certain part of the body by release system, which cannot affect other regions in the body.
