An Experiment of Using Nitinol Alloy Momemorial Stent to Treat the Stenosis of the Rabbi
- VernacularTitle:镍钛记忆合金支架治疗兔外耳道狭窄的实验研究
- Author:
Mengdong WANG
;
Zhichun HUANG
;
Jianxing GU
;
Baobin SUN
;
Xu FENG
- Publication Type:Journal Article
- Keywords:
Nitinol alloy memorial stent;
Ear;
external;
Cicatrix,hypertrophic;
Model,animal
- From:
Journal of Audiology and Speech Pathology
2010;18(2):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of nitinol alloy memorial stent with silastic tube in treating the stenosis of the rabbit.Methods 16 rabbits with external ear canal(EEC) stenosis were randomly divided into two groups.One group was implanted with skin on the EEC wound while the other not.By self-comparison method nitinol alloy memorial stem was implanted in a rabbit's one ear and the silastic tube in the other.After days 5,15,30,and 60 later,the diameters of the external ear canal (with two materials planted) were measured respectively in the skin-planting group.In the naked group scar tissues were harvested and tested separately according to the planting material.HE coloration were used to study fibroblast hyperplasty while RT-PCR were applied to detecting the TGFβ1mRNA expression.The two brackets were compared according to their effect to scar hyperplasty.Results The EEC diameters using nitinol alloy memorial stem were found more spacious than using silastic tube.HE coloration showed the fibroblast hyperplasia was more mitigatory by using the nitinol alloy memorial stent.RT-PCR also found the TGFβ1mRNA expression was low by using same material.Conclusion The nitinol alloy memorial stent shows obvious superiority over silastic tube in external ear canal stenosis therapy.
