Research and clinical application of nano-drug carriers
10.3969/j.issn.1673-8225.2010.08.024
- VernacularTitle:纳米药物载体的研究及临床应用
- Author:
Lixia JIN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2010;14(8):1429-1432
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND: Compared with ordinary preparation, nano-drug carriers have the advantages of prolonged drug effects, increased therapeutic effects and small toxicity. However, reports concerning the application of nanoparticles, nano-liposomes, polymer micelles, nano-smart drug, polymer nano-body medicine, Dendrimers and other nanoscale drug carriers are few. OBJECTIVE: To summarize the characteristics, types and preparation methods of nano-drug carriers, and to elucidate its research progress. METHODS: The Medline database was searched by computer with key words of "Nano-drug carriers, nanoparticles,nano-liposomes, clinical application" to find literatures published between January 1991 to December 2009, and the language was limited to English. Simultaneously, articles published from January 1994 to December 2009 were searched in Chinese Journal Full-text database with the same key words,and thelanguage was limited to Chinese.Inclusion criteria: ①Articles are closely related to the research of nano-drug carrier. ②Related researches published on core journals in the lates years were preferential in selection.Exclusion criteria: ①Repeatability study. ②Meta analysis. RESULTS AND CONCLUSION: A total of 360 documents were seized by primary screen, finally 28 sub-standard literatures entered further analysis, including 25 reviews and 3 clinical or basic experiments. The nano-drug carriers are characterized by specificity, targeting, accurate and absorbable, which can be used in preventing and curing disease. The combination of nano carriers and specific drugs can promote the development of nano-biotechnology, and provide a reliable basis for clinical diagnosis and treatment.
