Expression of Bcl-x and Its Clinical Significance in Endometrial Cancer
10.3969/j.issn.1000-8179.2010.06.003
- VernacularTitle:Bcl-x在不同子宫内膜组织中的表达及意义
- Author:
Yanhui ZHAO
;
Xiaoxin MA
;
Hong GAO
;
Ling HUANG
;
Yingnan JIN
- Publication Type:Journal Article
- Keywords:
Bcl-xl;
Bcl-xs;
Endometrial cancer
- From:
Chinese Journal of Clinical Oncology
2010;37(6):309-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to explore their correlation.Methods: The expression of Bcl-xl and Bcl-xs in 32 cases of endometrial carci-noma, 12 cases of endometrial atypical hyperplasia, 6 cases of endometrial simple hyperplasia and 10 cases of normal en-dometrial tissues were examined by RT-PCR and Western-blot.Results: The expression of Bcl-xl mRNA and protein was significantly higher in endometrial cancer tissues than in normal endometrial tissues (P<0.05), and was statistically associat-ed with the pathological stage of endometrial carcinoma.(F=5.33, P=0.02).The expression of Bcl-xs mRNA and protein in atypical endometrial hyperplasia and endometrial carcinoma tissues were significantlly lower than that in normal endometri-al tissues (P<0.05), which was also associated with clinical stage and lymph node metastasis of endometrial carcinoma (P<0.05).The expression of Bcl-xl was negatively correlated with the expression of Bcl-xs in different endometrial tissues (r=-0.76).Conclusion: The abnormal expression of Bcl-xs and Bcl-xl was a factor for the pathogenesis and development of endometrial carcinoma.The negative correlation between Bcl-xl and Bcl-xs in different endometrial tissues as well as their relative expression ratio may have certain impact on the genesis of endornetrial cancer.
