Analysis of Related Factors of Metachronous Liver Metastases in Patients with Dukes'C Colorectal Cancer
10.3969/j.issn.1000-8179.2010.06.004
- VernacularTitle:Dukes'C期结直肠癌异时性肝转移相关因素分析
- Author:
Chuanyuan LIU
;
Sen ZHANG
;
Feng GAO
;
Jungang LIU
;
Shen HUANG
- Publication Type:Journal Article
- Keywords:
Dukes'C stage;
Colorectal carcinoma;
Metachronous liver metastases;
Related factors
- From:
Chinese Journal of Clinical Oncology
2010;37(6):313-316
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical and pathological factors related to metachronous liver metastases in patients with Dukes'C colorectal cancer.Methods: A total of 170 patients with Dukes'C colorectal cancer treated with radical surgery in our hospital between January 2003 and December 2006 were reviewed.Factors including sex, age, tumor size (cm), depth of invasion, histological type, and serum CEA level were analyzed.Univariate and multivariate analyses were used to evaluate the factors concerned by Binary logistic regression (SPSS 13.0 for windows).Results: Of the 170 cases, 36 cases had metachronous liver metastases and 26 of them (72.2%) were found with metachronous liver metastases with-in two years after surgery.Thirty-two cases (88.9%) were identified with metachronous liver metastases within three years after surgery.Univariate analysis showed that depth of invasion, histological type and serum CEA level were predictors that could affect metachronous liver metastases.Depth of invasion and serum CEA level were independent risk factors for meta-chronous liver metastases of colorectal cancer.Multivariate analysis revealed that histological type was independent favor-able factor for metachronous liver metastases of colorectal cancer.Conclusion: Depth of invasion, histological type and se-rum CEA level were independent factors related to metachronous liver metastases of colorectal cancer.It is necessary to closely follow up Dukes'C colorectal cancer patients for two or three years after surgery in order to detect metachronous liv-er metastases early, especially for patients with higher preoperative serum CEA level or with tumor invasion to serosa.
