Clinical Analysis of the Effect of Rituximab in Combination with CTOP Chemotherapy on B Cell Non-Hodgkin's Malignant Lymphoma
10.3969/j.issn.1000-8179.2010.06.011
- VernacularTitle:美罗华联合CTOP方案治疗B细胞非霍奇金淋巴瘤35例临床分析
- Author:
Xia HAN
;
Huaqing WANG
;
Xianming LIU
;
Lihua QIU
;
Huilai ZHANG
;
Zhengzi QIAN
;
Wei EI
;
Xiuzhen CUI
;
Xishan HAO
- Publication Type:Journal Article
- Keywords:
Rituximab;
Non-Hodgkin's lymphoma;
Chemotherapy
- From:
Chinese Journal of Clinical Oncology
2010;37(6):338-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the efficacy and toxicity of rituximab combined with cyclophosphamide, pirarubicin, vincristine, and prednisone (R-CTOP regimen) for B cell non-Hodgkin's lymphoma and to analyze the influential factors for patient response.Methods: The clinical data of patients with CD20 antigen treated with R-CTOP regimen were reviewed and the influence of sex, age, clinical stage, pathological type, and level of LDH and IPI on patient response was analyzed.Results: A total of 33 patients were evaluated for objective response.The complete response (CR) rate was 51.5%, the par-ticel response (PR) rate was 33.3%, and the overall response rate was 84.8%.For the 23 de novo patients, the CR rate was 56.5 %, the PR rate was 34.8%, and the OR rate was 91.3%.While in the 10 recurrent patients, the CR rate was 40%, the PR rate was 30%, and the OR rate was 70%.Sex, clinical stage, pathological type, and the level of LDH and IPI were not significantly related to clinical response.While patient age was related to clinical response.None of the patients died of therapy-related side effects.The most frequent adverse event was myelosuppression (Ⅲ-Ⅳ decrease of leukocyte account-ed for 32.1%).Cardiotoxicity and alopecia were mostly grade Ⅰ to grade Ⅱ.Other side effects can be tolerated after symp-tomatic treatment.Conclusion: R-CTOP regimen is a highly effective and well-toleraed therapy and should be the first choice in the treatment for B cell non-Hodgkin's lymphoma (NHL), especially for senior patients.
