Multivariate Analysis of the Survival of 109 Lung Adenocarcinoma Patients with Brain Metastases
10.3969/j.issn.1000-8179.2010.06.013
- VernacularTitle:影响109例肺腺癌脑转移患者生存的多因素分析
- Author:
Chunwa WU
;
Kai LI
- Publication Type:Journal Article
- Keywords:
Lung neoplasm;
Brain metastases;
Prognostic factors;
Retrospective analysis
- From:
Chinese Journal of Clinical Oncology
2010;37(6):345-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate prognostic factors of survival of lung adenocarcinoma patients with brain metasta-ses.Methods: The clinical data of 109 lung adenocarcinoma patients with brain metastases were reviewed.Fifty-senven pa-tients survived more than 1 year, and 52 patients survived less than 1 year.The data were analyzed by SPSS 15.0 statisti-cal software.Results: Both the univariate analysis and multivariate analysis showed that patients' PS score, the interval be-tween diagnosis and brain metastasis, and multimodality treatment were independent prognostic factors for the survival of lung adenocarcinoma patients with brain metastases (P<0.05).Patients' gender, age, metastatic symptoms and extracrani-al metastases didn't significantly affect patient survival.Conclusion: Patients with PS score 0-1, the interval of more than 1 year between diagnosis and brain metastasis, and combined therapy have longer survival.The research provides an impor-tant guidance for the treatment of advanced lung adenocarcinoma patients with brain metastases.
