Effect of interventional thermochemotherapy on VX2 transplanted hepatic tumor model: a comparative study with interventional chemotherapy in experimental rabbits
- VernacularTitle:介入性灌注化疗与热灌注化疗对兔VX2肝癌模型的作用比较研究
- Author:
Weidong GONG
;
Yazhou LI
;
Heng WANG
;
Daihui NI
;
Wei YANG
;
Zhimin WANG
;
Zhiqun WU
- Publication Type:Journal Article
- Keywords:
intercentional thermochemotherapy;
rabbit VX2 hepatic tumor model;
effectiveness
- From:Journal of Interventional Radiology
2010;19(3):208-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness and safety of interventional thermochemotherapy for VX2 transplanted hepatic tumor model in experimental rabbits.Methods The hepatic tumor model was established in 20 New Zealand rabbits by implanting VX2 tumor cells into the right hepatic lobes of the rabbits.The rabbits were randomly and equally divided into two groups with 10 rabbits in each group:group A (study group)and group B(control group).Via the femoral access,the catheter was placed into the tumorfeeding artery,which was confirmed by DSA.The rabbits in group A received an infusion of 100 ml 5% glucose plus 5-Fu(20 mg/kg)at 60℃ temperature,while the rabbits in group B received an infusion of 100 ml 5% glucose plus 5-Fu(20 mg/kg)at normal room temperature(22-25℃).Before and after the procedure,the tumor size was measured by means of B ultrasonography and the serum ALT was estimated to assess the liver function.The results were statistically compared between two groups.Results After the treatment,the tumor size in group A(study group)became much smaller than that in group B(control group),with P＜0.05.And no significant difference in the serum ALT level existed between group A and group B.Conclusion The interventional thermochemotherapy is superior to interventional chemotherapy in inhibiting VX2 transplanted hepatic tumor in experimental rabbits.
