Research on the clinical application value of bone turnover markers in bone metastases from non-small cell lung cancer
- VernacularTitle:骨转换标志物在非小细胞肺癌骨转移临床应用中价值的研究
- Author:
Zhiyu WANG
;
Chen YANG
;
Yunchao GAO
;
Zan SHEN
;
Yumei YANG
;
Hui ZHAO
;
Yang YAO
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
bone metastasis;
bone turnover markers
- From:
China Oncology
2010;20(3):202-206
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Bone metastases leads to the destruction of bones by changing the level of bone turnover markers.The purpose of this study was to assess the clinical application value of bone turnover markers in bone metastases for non-small cell lung cancer,which included the diagnosis and spread behavior of bone metastases.Methods:AKP,β-CTx,OST and BALP were measured in 76 NSCLC with bone metastases patients and 44 normal people.Results:The level ofAKP,β-CTx and BALP in patients with bone metastasis was significantly higher than in the subjects without bone metastases.There were significant correlations among the bone turnover markers.The levels of BALP and OST were significantly positively correlated with the extent of bone metastasis.Patients with high-levels of CTx and low-levels of BALP had a higher risk of pathologic fracture.Conclusion:In patients with bone metastases from NSCLC,bone turnover markers can help make diagnoses and evaluate severity of disease.It potentially has a wide range of uses in clinical practice.
