Effect of Aortic Valve Regurgitation on Pharmacodynamics of Cisatracurium
- VernacularTitle:主动脉瓣返流对顺式阿曲库铵临床药效学的影响
- Author:
Mingfang XIANG
;
Yalan LI
;
Sheng WANG
- Publication Type:Journal Article
- Keywords:
aortic valve regurgitation;
cisatracurium;
pharmacodynamics
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(2):306-308
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]The purpose of this study was to investigate the effect of severe aortic valve incompetence on the pharmacodynamics of cisatracurium.[Methods]Thirty patients were enrolled in this study:15 patients with severe aortic valve incompetence scheduled for aortic valve replacement were included in the study group(AI-group)and 15 patients without heart disease undergoing general surgical operations were allocated into the control group(C-group).Anesthesia was induced with fentanyl 5 μg/kg.propofol 1.5～2 mg/kg and cisatracurium 0.1 mg/kg and maintained by total intravenous anesthesia with propofol-remifentanil infusion.Degree of neuromuscular block was measured by train-of-four ratio using TOF-WATCH acceleragraph monitor.Onset time(from administration of cisatracurium to T1=0),total twitch suppression time,the time for spontaneous recovery of T1 to 25%and 75%.and the recovery index were recorded respectively.[Results]The onset time of cisatracurium was significantly longer in the AI group compared to the control group(5.6±0.8 min vs 3.4 ±0.4 min.P＜0.001.However.there was no difference in the recovery time between the two groups.[Conclusion]We demonstrated that the onset of cisatracurium was delayed in the patients with severe aortic regurgitation in comparison to those without heart disease.
