MRI Features of Neuropsychiatric Abnormalities in Systemic Lupus Erythematosus

VernacularTitle:系统性红斑狼疮性脑病的MRI表现
Author: Chengzhou ZHANG ; Jing ZHANG ; Huiming YI ; Wei LI ; Ping WANG
Publication Type:Journal Article
Keywords: systemic lupus erythematosus; brain; MR imaging
From: Journal of Practical Radiology 2010;26(4):466-469
CountryChina
Language:Chinese
Abstract: Objective To evaluate the MRI features of neuropsychiatric abnormalities in systemic lupus erythematosus(NPSLE).Methods Brain MRI images of 21 cases with NPSLE confirmed by clinic were analyzed retrospectively.ADC values of the lesions and normal brain tissue were measured.Results Brain abnormal MRI findings in 20/21 cases were found(95%)including:(1)High signal intensity on DWI in 14 cases,11 were diffuse lesions,3 were focal lesions,4 of 14 combined with brain atrophy.The lesions mostly localized in white matter.The ADC values of the lesions in gray matter were decreased(t=2.513,P=0.019),while the ADC values of the lesions in white matter were increased(t=2.877,P=0.007).(2)2 cases only showed brain atrophy.(3)Leukoaraiosis presented in 2 cases.(4)Encephalomalacie presented in 2 cases,1 accompanied with brain atrophy.(5)No enhancement(3/5)and little patchy enhancement(2/5)were observed at contrast MRI study.Conclusion MRI plays an important role in displaying cerebral lesions and the location of it,progression and succession of NPSLE.