Association between HLA-DRB1 allele polymorphism and susceptibility to chronic myelogenous leukemia in Chinese Han
10.3969/j.issn.1000-484X.2010.04.005
- VernacularTitle:HLA-DRB1基因多态性与慢性髓性白血病的相关性研究
- Author:
Mingrui HUO
;
Haiyan LIU
;
Yan YU
;
Bin XI
;
Xiaojun HUANG
;
Dan LI
- Publication Type:Journal Article
- Keywords:
HLA-DRB1 gene;
Chronic myelogenous leukemia;
Genetic polymorphism;
Gene frequency
- From:
Chinese Journal of Immunology
2010;26(4):309-311
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The aim was to explore the association between the HLA-DRB1 allele polymorphism and susceptibility to chronic myelogenous leukemia(CML)in Chinese Han population.Methods: The polymorphism of HLA-DRB1 alleles in 762 CML patients and 2 264 normal umbihcal cord blood samples were tested by polymerase chain reaction with sequence specific primer(PCR-SSP).Results: The most common allele in DRB1 locus in normal population was DRB1 * 15(17.25%), whereas DRB1 * 10 was the least frequent allele(1.39%).Compared with normal controls, the frequency of HLA-DRB1 * 08 was significantly increased in all CML groups(7.48%vs 5.39%, X~2 =8.963,OR= 1.023, P =0.004)and CML male groups(7.72%vs 5.39%,X~2 = 8.059,OR= 1.025,P = 0.007).But there was no significant difference between the normal controls and CML female patients.Conclusion: It should be concluded that DRB1 * 08 could be considered a susceptible allele for CML male patients.
