Study on gatifloxacin in situ pH-sensitive gel release in vitro
- VernacularTitle:加替沙星pH敏感眼用原位凝胶体外释放的研究
- Author:
Yajing XU
;
Rongfeng HU
;
Hui YIN
;
Yu GAO
- Publication Type:Journal Article
- Keywords:
gatifloxacin;
pH-sensitive;
in situ gel;
drug release;
in vitro
- From:
Chinese Journal of Biochemical Pharmaceutics
2010;31(2):107-110
- CountryChina
- Language:Chinese
-
Abstract:
purpose To investigate the release properties of gatifloxacin in situ pH-sensitive gel in vitro.Methods The improved paddle method and the membraneless model were applied in assessing the drug release behavior.Results The gel erosion and drug release were increased with the increase of surface area and shaking frequency.The cumulative quantities of gel erosion were well correlated with the cumulative release of drug loaded in the gel.Conclusion Gatifloxacin was released from in situ pH-sensitive gel with zero-order kinetics characters,and drug release was mainly controlled by gel erosion.
