Effect of paeonol on inflammatory factors after focal cerebral ischemia-reperfusion injury in rats
- VernacularTitle:丹皮酚对大鼠脑缺血再灌注损伤炎性细胞因子的作用
- Author:
Qing YANG
;
Jibiao WU
;
Xiumei ZHANG
- Publication Type:Journal Article
- Keywords:
paeonol;
ischemia-reperfusion;
TNF-α;
IL-1β
- From:
Chinese Journal of Biochemical Pharmaceutics
2010;31(2):111-113
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the effect of paeonol on inflammatory factors after focal cerebral ischemiareperfusion injury in rats and its possible mechanism of paeonol.Methods Focal cerebral ischemic model was established by MCAO in rats.After 2 hours of cerebral ischemia and 22 hours of reperfusion,the expression of TNF-α and IL-1β in brain was determined by immunohistochemistry.The content of TNF-α and IL-1β in serum was measured by ELISA.Results Compared with model group,the levels of TNF-α and IL-1β in brain and serum in rats in the paeonol groups were obviously decreased.Conclusion Paeonol could relieve brain damage induced by focal cerebral ischemia-reperfusion,which may be related to inhibiting the production of inflammatory factors.
