A Series Studies on Mechanism of TGF-β/Smads in Peritoneal Fibrosis and Regulating Pathway
- VernacularTitle:TGF-β/smads与腹膜纤维化及调节机制系列研究
- Author:
Xueqing YU
- Publication Type:Journal Article
- Keywords:
transforming growth factor-β;
signaling protein smads;
peritoneal fibrosis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(2):161-165
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal fibrosis is the most important complication in maintenance of peritoneal dialysis(PD),also the main reason of the changes in peritoneal structure and function,the important factor affecting the long-term survival and prognosis in PD patients.TGF-β is a multifunctional growth factor and also a key factor in organ and tissue fibrosis.We had carried out the following series studies focused on the mechanism and regulatory factors of TGF-β and its signaling proteins-Smads,in peritoneal fibrosis:①the role and mechanism of TGF-β in peritoneal fibrosis;②Over-expressed Smad7 in prevention and treatment of peritoneal fibrosis;③the role and mechanism of TGF-β/Smad in acute peritonitis;④crosstalk between TGF-β and other signaling pathways.The Results showed that,TGF-β1/Smads signaling pathway played a crucial role in the process of peritoneal fibrosis,and over-expression of inhibitory signaling protein Samd7 had potential clinical value in prevention and treatment of PD-related peritoneal fibrosis.
