Assessment on the influence of pentafluoropropyloxydihydroartemisinin and mefloquine on the function of the nervous system in mice
- Author:
Truong Van Nhu
- Publication Type:Journal Article
- Keywords:
nervous, drug
- MeSH:
Nervous System;
Pharmaceutical Preparations;
Mice;
drugs;
artemisinins
- From:Journal of Malaria and parasite diseases Control
2003;0(6):37-42
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Preclinical trial of effects of pentafluoropropyloxydihydroartemisinin (BB203) and mefloquine on nervous functions was carried out in white mice. BB103 with doses of 50mg/kg x 5 days didn’t affect to conditional reflex of searching for food in mice, but BB103 with doses of 100mg/kg x 5 days did. Use mefloquine with doses of 50mg/kg x 5 days and 100mg/kg x 5 days that had significantly increased the speed of establishment of reflex, speed of establishment of stable reflex, number of times with consolidation to extinguish the reflex
