Effects of adenosine on left coronary blood flow and flow reserve in mini-swine: a comparative study between different adenosine doses
- VernacularTitle:对比不同剂量腺苷对小型猪左冠状动脉血流及血流储备的影响
- Author:
Qingyong ZHANG
;
Zhihua WANG
;
Ruiming YAO
;
Junbo GE
;
Jingbo LI
;
Meng WEI
- Publication Type:Journal Article
- Keywords:
coronary blood flow;
coronary flow reserve;
adenosine;
mini-swine
- From:
Journal of Interventional Radiology
2010;19(4):318-321
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of different doses of adenosine(AD)on the left coronary blood flow(CBF)and left coronary flow reserve(CFR)in mini-swine.Methods By using Doppler flow wire and intracoronary ultrasound imaging catheter at the middle segment of LAD,coronary average peak flow velocity(APV)and lumen area were measured in 10 healthy mini-swines.CBF was calculated from the equation of 0.6 APV times 0.5 lumen area.Intracoronary bolus injection of different dose AD(12μg,18μg,24 μg and 36μg,separately)was used to induce maximal coronary hyperemic reaction.CFR was defined as the ratio of hyperemic CBF to resting CBF.Results Intracoronary bolus injection of 18μg AD level induced a maximal coronary vasodilation.Significant difference in the hyperemic CBF existed between 12 μg AD dose and 24μg or 36μg AD dose(P＜0.05).No significant difference in heart rate,blood pressure,rCBF and CFR was found among three different AD dose groups(18μg,24μg,and 36μg).Conclusion CBF and CFR in mini-swine can be effectively assessed by bolus injection of AD with the dose of(18～24)μg.
