Biocompatibility of electro-spinning beta-tricalcium phosphate/gelatin guided tissue regeneration menbrene versus polylactic acid and poly(lactide-co-glycolide) membrane
10.3969/j.issn.1673-8225.2010.16.014
- VernacularTitle:比较电纺β-磷酸三钙/明胶引导组织再生膜与聚乳酸、聚丙交酯/乙交酯膜的生物相容性
- Author:
Junyuan ZHENG
;
Ming TANG
;
Xuliang DENG
;
Xiaoping YANG
;
Shen ZHANG
;
Xiaoxia LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2010;14(16):2903-2906
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: In the past, guided tissue regeneration materials were produced by 13-tricalcium phosphate (β-TCP) and gelatin (Gel), but the production of fiber membrane by electro-spinning technique was reported less.OBJECTIVE: To prepare a new kind of Gel with β-TCP hybrid nanofibrous membrane and testing its biocompatibility compared with polylactic acid (PLLA) and poly(lactide-co-glycolide) (PLGA) membrane.METHODS: The β-TCP/Gel guided tissue regeneration membrane was made by electro-spinning technique.Scanning electron microscopy (SEM) was employed to observe membrane surface.MTT test was performed to compare toxicity among β-TCP/Gel,PLLA, and PLGA membranes.RESULTS AND CONCLUSION: The β-TCP/Gel membrane was porous, and β-TCP granules were nodosity-adhered on surface of Gel.The average diameter of fiber was 500-600 nm.The distribution of fiber ranged from 200 to 500 nm.There was no significant difference in toxicity among PLLA, PLGA, and negative control group (P > 0.05).The results suggested that the β-TCP /Gel membrane was low cytotoxicity and suitable for tissue engineering.It would be a promising material for periodontal tissue regeneration.
