Some techniques for genotyping of hepatitis C virus
- Author:
Truong Xuan Lien
- Publication Type:Journal Article
- Keywords:
Genotype;
Subtype;
Hepatitis C virus;
- MeSH:
Hepacivirus;
Viruses
- From:Journal of Preventive Medicine
2005;15(1):79-83
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Genotypes of hepatitis C virus are clinically relevant to epidemiology, prognosis and therapeutical management of HCV infection. Our study aims to compare different methods for HCV genotyping. Hepatitis C genotypes and subtypes of infected patients in Ho Chi Minh city was determined by serological typing using HCV serotyping 1-6 (Murex company), by molecular typing using Innolipa HCV II assay (Innogenetics NY) and direct sequencing of core and NS5b region. Our results show that the hepatitis C virus by analysing the sequences of the core and NS5b regions gave concordant results. The NS5b region is reliable for the identification of HCV subtype 6 circulating in Viet Nam.
