Research and progress of microcarrier culture technology
10.3969/j.issn.1673-8225.2010.16.024
- VernacularTitle:微载体培养技术的研究与进展
- Author:
Yan ZHOU
;
Baolin LIU
;
Bo YANG
;
Xin WANG
;
Chenghong PENG
;
Baosan HAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2010;14(16):2945-2948
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Microcarrier culture technology has become a new and large scale cell culture technology. It has been mainly used in the amplification research of tissue engineering seed cells. Microcarder possesses the advantage of larger surface area and plays an essential role in microcarrier culture technology.OBJECTIVE: To sum up the biomaterials and methods of microcarrier preparation, and provide theoretical foundation for the study of microcarrier culture technology and tissue engineering.METHODS: Articles were retrieved from PubMed, Wanfang, and VIP databases with the key words of "micrecarrier, biomaterials cell culture, tissue englneering" in both English and Chinese between 1967/2009 and 1990/2009, respectively. Inclusion criteria:study addressing microcarrier materials, preparation, and performance; study of microcerrier cell culture; animal experiments and clinical applications. A total of 34 articles were originally retrieved based on their titles and abstracts.RESULTS AND CONCLUSION: Although a lot of studies have reported research and preparation of microcarrier, clinical application remains still difficult. Recently, varying materials will be made into novel compound materials by new technology,which can adjust mechanics and biodegredation of microcarder via surface modification.
