Repairing articular cartilage and subchondral bone defects with polyurethane/nano-hydroxyapatite+polyamide66 composite
10.3969/j.issn.1673-8225.2010.16.009
- VernacularTitle:聚氨酯/纳米羟基磷灰石+聚酰胺66一体化复合支架材料修复软骨及软骨下骨缺
- Author:
Chao PENG
;
Zhongpeng GUO
;
Dianming JIANG
;
Hong AN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2010;14(16):2883-2887
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Cartilage stent materials were abundant. With the development of preparation technique, structure, and surface modification technique, performance of materials were improved remarkably; thus, Integrated-repaidng defects of articular cartilage and subchondral bone required high stability of cartilage replacement materials.OBJECTIVE: To evaluate the effect of polyurethane/nano-hydroxyapatite+polyamide66 (PU/n-HA+PA66) biological composite material on repairing articular cartilage and subchondral bone.METHODS: Twenty dog models were randomly divided into 4 groups: porous PU/n-HA+PA66 implant group, compact PU/n-HA+PA66 implant group, n-HA+PA66 implant group and blank control group. The macroscopic and histological evaluations were performed at 4, 12, and 24 weeks postoperatively. The interfaces of biomaterial implants with articular cartilage were observed by scanning electron microscope.RESULTS AND CONCLUSION: After 12 and 24 weeks, bone tissue grew into lower layer materials. Porous PU was well fused with peripheral cartilage. At 24 weeks postoperatively, the porous PU was closely connected with surrounding articular cartilage than the compact PU, and the articular cartilage surrounding the compact PU degenerated obviously. PU/n-HA+PA66 had a similar structure with normal cartilage and subchondral bone and had remarkable effects on repairing defects of articular cartilage and subchondral bone.
