Tissue-engineered tendon repairing tendon tissue defect induced by movement training: A correlated research of cell materials
10.3969/j.issn.1673-8225.2010.16.031
- VernacularTitle:组织工程化肌腱修复运动训练致肌腱组织缺损:细胞材料及其过程中的相关研究
- Author:
Hongyu SI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2010;14(16):2975-2978
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND: Traditionally, tendon was repaired by autoallergic tendon transplantation and transfusion; however, both methods were limited by supply region and additional trauma, and the development was slowed down.OBJECTIVE: To summarize biomechanical characteristics of seed cells, stent, and bioreactor during repairing tendon tissue defect, and provide prevention and cure of tendon injury induced by training and competition.METHODS: A computer-based online search was conducted in VIP database with the keywords of "movement training, tendon tissue, repair" from January 2004 to October 2009.Articles which were related to tendon tissue injury induced by movement training were included, but articles related to duplicated research or Meta analysis were excluded.RESULTS AND CONCLUSION: Tissue-engineered tendon has achieved therapeutic effects to a certain degree; however, it is still not used for clinical application.Source of seed cells was restrict to autoallergic tendon cells; on the other hand, comparison between fibroblast and tendon cells, gene chip was used to modify gene in order to solve source of seed cells of tissue-engineered tendon.During regeneration of tendon, normal mechanical stimulation played an important role in moulding of newborn tendon.Because the stimulation might induce orientation arrangement of newborn collagen fiber, enhance mechanical strength of newborn tendon, make sure the functional training as eady as possibly, effectively reduce tendon adhesion, and provide an ideal stent for great circulation of tendon repairing.Scientific training is necessary for coaches and athletes to avoid from tendon tissue injury during movement training and competition.Although tendon tissue engineering has developed well, it still brings adverse effect on body and mind.
