Expression of 2 transcripts of NGX6 gene in colorectal cancer and the correlation with carcinoembryonic antigen
10.3969/j.issn.1672-7347.2010.05.001
- VernacularTitle:NGX6基因两转录本在不同分期结直肠癌中的表达及与癌胚抗原的关系
- Author:
Zheng SU
;
Xiaoyan WANG
;
Shourong SHEN
;
Li WANG
;
Yu LI
;
Nan LI
;
Zeng LI
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
NGX6 gene;
transcript;
carcinoembryonic antigen
- From:
Journal of Central South University(Medical Sciences)
2010;35(5):401-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and function of NGX6-S (short transcript) and NGX6-L (long transcript) in colorectal cancer. Methods In situ hybridization was used to detect the expression of these 2 transcripts in colorectal cancer tissues and paired normal tissues, and analyze the correlation between NGX6 and carcinoembryonic antigen (CEA). Results The expression of NGX6-S was higher than that of NGX6-L in the colorectal cancer tissues (P=0.008). The expressions of NGX6-S and NGX6-L were not different among the 4 stages of colorectal cancer (P＞0.05). The expression of NGX6-S in the colorectal cancer tissues of Duke A, B, and C stages had no difference with that of the paired normal tissues (P＞0.05). Inversely, the expression of NGX6-S in the colorectal cancer tissues of Duke D stage was lower than that in the paired normal tissues (P=0.033). NGX6-L expression was not different between the colorectal cancer tissues and the paired normal tissues in 4 stages(P＞0.05).The expression of NGX6-S and NGX6-L had no correlation with the serum concentration of CEA. Conclusion NGX6-S may play an important role in colorectal cancer, and the lowered expression of NGX6-S may contribute to the distant metastasis of colorectal cancer.
