Ion Channels as Antivirus Targets
10.1007/s12250-010-3136-y
- Author:
Xin LIANG
;
Zhiyuan LI
- Publication Type:Journal Article
- Keywords:
Viral ion channel;
Antiviral therapy;
Viruses;
Amantadine
- From:
Virologica Sinica
2010;25(4):267-280
- CountryChina
- Language:Chinese
-
Abstract:
Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle.They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or cellular activity.We will discuss a group of viral channel proteins that belong to the viroproin family,and which participate in a number of viral functions including promoting the release of viral particles from cells.Blocking these channel-forming proteins may be"lethal",which can be a suitable and potential therapeutic strategy.In this review we discuss seven ion channels of viruses which can lead serious infections in human beings: M2 of influenza A,NB and BM2 of influenza B,CM2 of influenza C,Vpu of HIV-1,p7 of HCV and 2B of picornaviruses.
