Expression of interleukin-17 in peripheral blood of patients with systemic lupus erythematosus and its correlation with disease activity
- VernacularTitle:系统性红斑狼疮患者外周血IL-17表达及其与疾病活动性的关系
- Author:
Xue XU
;
Hejian ZOU
;
Lin LV
- Publication Type:Journal Article
- Keywords:
systemic lupus erythematosus;
interleukin-17;
activitiy;
correlation
- From:
Fudan University Journal of Medical Sciences
2010;37(1):71-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the protein and mRNA levels of interleukin-17 (IL-17) in the peripheral blood of patients with systemic lupus erythematosus (SLE), and to analyze the relationship between IL-17 and disease activity. Methods Twenty-six hospitalized SLE patients and twenty-one normal controls were studied. Plasma protein and mRNA of IL-17 in peripheral blood were measured by ELISA and Real-time RT-PCR respectively. Results IL-17 level and its mRNA level increased in SLE patients compared with that in normal controls. Plasma concentration of IL-17 showed a significant positive correlation with SLEDAI score and anti-dsDNA antibody level, and a significant negative correlation with serum C3 level. Conclusions Plasma IL-17 protein and mRNA expression level in SLE patients increased significantly and had close relationship with disease activity, which might suggest that IL-17 play an important role in the pathogenesis of SLE.
