Correlating estrogen receptor-alpha Pvull genetic polymorphism with bone mass index in premenopausal Han Chinese women from Nanchang region
10.3969/j.issn.1673-8225.2010.33.045
- VernacularTitle:南昌地区汉族绝经前女性雌激素受体α基因Pvull遗传多态性与体质量指数的关系
- Author:
Hong XU
;
Jing PENG
;
Li ZHANG
;
Lin ZOU
;
Haibin KUANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2010;14(33):6267-6270
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Obesity is serious complex disease determined by multiple genetic factors. Body mass index (BMI) is a common phenotype for obesity. Although some candidate genes have been shown to be related with BMI variation, the underlying substantial relationship remains poorly understood.OBJECTIVE: To investigate whether estrogen receptor-α (ER-α) Pvull genetic polymorphism is associated with BMI variation.METHODS: In total 390 premenopausal women from a local population of Nanchang City in Jiangxi Province People's Hospital.Body weight and height were measured. All participants were genotyped at the ER-α Pvull locus using polymerase chain reaction-restriction fragment length polymorphism.RESULTS AND CONCLUSION: The ER-α Pvull genotype frequencies of PP, Pp and pp were 0.133, 0.485 and 0.382,respectively. The distribution of ER-Pvull genotypes was in accordance with Hardy-Weinberg equilibrium (HWE) (P ＞ 0.05).There was no significant correlation between ER-α Pvull genetic polymorphism and BMI variation (P = 0.338). These findings indicate that ER-α Pvull genetic polymorphism does not greatly affect BMI variation of premenopausal women in Nanchang region.
