Effect of Naoling decoction on iNOS expression in hippocampal CA3 region in rats with synthetic Alzheimer's disease
10.3969/j.issn.1672-7347.2010.09.002
- VernacularTitle:脑灵汤对阿尔茨海默病模型大鼠海马CA3区域iNOS蛋白表达的影响
- Author:
Bingwu ZHONG
;
Zhe WANG
;
Mingda HE
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
β-amyloid polypeptide;
Naoling decoction;
iNOS;
rat
- From:
Journal of Central South University(Medical Sciences)
2010;35(9):910-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Naoling decoction on the expression of iNOS in hippocamal CA3 region in rats with Alzheimer's disease (AD), and to explore the potential mechanism. Methods Forty SD rats were classified into 5 groups: a normal group, a sham operated group, an AD group, a Naoling decoction group, and a Naofukang group. The Alzheimer's disease model was established by injecting Aβ1-42 into the hippocamal in the rats. Expression of iNOS in the CA3 region was measured with immunohistochemical staining. Results Compared with the normal group, the expression of iNOS protein in the hippocampal CA3 fields in the AD group increased (P<0.05). Naoling decoction decreased the iNOS expression. Conclusion Naoling decoction can significantly reduce the expression of iNOS in the AD model rats, suggesting that Naoling decoction can be used for AD rats.
