Antiviral Activity of the Effective Monomers from Folium Isatidis Against Influenza Virus in Vivo
10.1007/s12250-010-3142-0
- Author:
Zhao LIU
;
Zhanqiu YANG
;
Hong XIAO
- Publication Type:Journal Article
- Keywords:
Folium Isatidis;
Monomers;
Influenza virus;
Antiviral activity;
In vivo
- From:
Virologica Sinica
2010;25(6):445-451
- CountryChina
- Language:Chinese
-
Abstract:
In order to evaluate the anti-influenza virus activity of the effective monomer from Folium Isatidis (FI) in vivo, we established mice model with viral pneumonia and divided them into 3 different dose groups, then observed their lung indexes, pulmonary pathological changes, pulmonary virus hemagglitination titers, living time and death rates. The results showed that the monomer could reduce the pulmonary index from 2.64 to 1.93, 1.63 and 1.40 (P<0.01) and decrease the hemagglitination titer from 1.15 to 0.84, 0.70 and 0.59 (P<0.01). In addition,the living time from 5.1d to 6.5d, 8.4d and 8.9d respectively(P<0.01). The high dose (75 mg/kg/d) has the similar effect with 100 mg/kg/d dose of virazole(P>0.05), and more effective than 200 mg/kg/d dose of antiviral liquor (P<0.05).
