Neuroprotective effect of salidroside
10.3760/cma.j.issn.1673-4165.2011.02.012
- VernacularTitle:红景天苷的神经保护作用
- Author:
Mingfa ZHANG
;
Yaqin SHEN
- Publication Type:Journal Article
- Keywords:
Salidroside;
Brain ischemia;
Neuroprotective angents;
Oxidative stress
- From:
International Journal of Cerebrovascular Diseases
2011;19(2):137-141
- CountryChina
- Language:Chinese
-
Abstract:
In vitro and in vivo animal model experiments have found that salidroside has protective effect for various causes induced injuries in various neurons and brain tissue.Its mechanisms of neuroprotection are multiple:(1)Protecting neurons from apoptotic injury by resisting oxidative stress,preventing intracellular Ca2 + overload,inhibiting caspase-3 activation,and attenuating hypoxia-induced abnormal metabolism of amyloid precursor protein;(2)promoting directional differentiation of stem cells into neurons and inducing neuronal regeneration;(3)promoting erythropoietin stimulating erythroblasts to be differentiated into erythrocytes and decreasing cerebrovascular resistance,and improving cerebral hypoxia-ischemia.Salidroside is expected to be used in the prevention and treatment of cerebral ischemic and neurodegenerative diseases,such as cerebral infarction,Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,and diabetic encephalopathy.
