Progress of metabolomics in children with nervous system disease
10.3760/cma.j.issn.1673-4408.2011.02.005
- VernacularTitle:代谢组学技术及其在儿童神经领域的研究进展
- Author:
Xiaotun REN
- Publication Type:Journal Article
- Keywords:
Metabonomics;
Children nervous disease;
Heredity metabolic disease
- From:
International Journal of Pediatrics
2011;38(2):111-113
- CountryChina
- Language:Chinese
-
Abstract:
Metabolomics, the measurement of metabolite concentrations and fluxes in cell systems, is an emerging science that has enormous potential and good application prospect. Metabolomics technology, especially mass spectrometry, has been used extensively in screening children's heredity metabolic disease, and part of these diseases has become to be curing. In this review, we elaborate on the application of metabolomics in early diagnosis of central nervous system infectious disease, screening of lipide metabolism dysfunction in nervous system and childhood autism, with special focus on the finding of cholesterin storage in nerve cell, variations in the metabolism of glucose, which give its promise for diagnosis and treatment of the lipide metabolism dysfunction in nervous system.
