The function of soluble form of CD163 in severe infection and sepsis
10.3760/cma.j.issn.1673-4912.2011.02.031
- VernacularTitle:可溶性CD163与严重感染及脓毒症的关系研究进展
- Author:
Yun CUI
- Publication Type:Journal Article
- Keywords:
Severe infection;
Sepsis;
Soluble CD163
- From:
Chinese Pediatric Emergency Medicine
2011;18(2):175-177
- CountryChina
- Language:Chinese
-
Abstract:
CD163 is one of transmembrane glycoproteins expressed only in activated monocyte-macrophage cell membrane, which acts as a marker of activated macrophages. In sepsis, CD163 activates the intracellular signal transduction pathways in macrophages,regulates TNF-α, IL-10 and IL-6 expression, have antiinflammatory and antioxidant effects in the inflammatory process. Soluble CD163 (sCD163) is a soluble form of CD163 ,which could play anti-inflammatory and immunoregulatory effects by inhibiting T cells proliferation and activation. Serum concentration of sCD163 may be highly increased when severe infection. Detection of serum sCD163 is helpful to diagnose sepsis,and to evaluate the prognosis of severe infection and sepsis.
