Brain natriuretic peptide rs198388 polymorphism and essential hypertension in Hunan Han people
10.3969/j.issn.1672-7347.2010.12.001
- VernacularTitle:脑钠素rs198388基因多态性与湖南汉族人群原发性高血压易感性的关联
- Author:
Min CHEN
;
Xiaoping CHEN
;
Yijie GUO
;
Ruizheng SHI
;
Guogang ZHANG
- Publication Type:Journal Article
- Keywords:
essential hypertension;
brain natriuretic peptide;
gene;
polymorphism
- From:
Journal of Central South University(Medical Sciences)
2010;35(12):1207-1213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between brain natriuretic peptide (BNP) rs198388 polymorphism and the susceptibility of essential hypertension in Han population of Hunan. Methods A total of 567 patients with hypertension (the hypertension group) and 555 healthy volunteers (the control group) were enrolled. Gender, age, smoking and drinking history of the 2 groups were not significantly different. Blood pressure was measured in the 2 groups. After fasting for 12 h or more, blood glucose, total cholesterol, triglycerides, high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured. DNA polymorphism analysis was done by polymerase chain reaction-restriction fragment length polymorphism method, and genotype was determined by agarose gel electrophoresis. Results The GG, GA, and AA genotypeswere detected.The frequencies of GA and AA genotypes and A allele were significantly lower in the hypertension group (GA and AA:12.3%;A:6.9%) than those in the control group (GA and AA:18.4%; A:9.7%; P=0.009, and P=0.014, respectively). Conclusion BNP rs198388 polymorphism may be associated with essential hypertension in Han people in Hunan. Carrying rs198388 GA and AA genotypes and A allele may be the reason for low risk of hypertension.
