The inhibitory effect of chemotherapeutic drugs on the proliferation of Bel-740 2 cells
- VernacularTitle:化学治疗药物对肝癌细胞增殖抑制作用的观察
- Author:
Jianping ZHU
;
Guoyou CAI
;
Ziwei SHEN
- Publication Type:Journal Article
- From:
Chinese Journal of General Surgery
2001;16(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the in vitro effect of che motherapeutant on hepatic carcinoma. Methods The inhibitory effect of 5-Fu, DDP and 4-PA on Bel-7402 cel ls proliferation was studied by MTT colorimetry. Resu lts (1) Bel-7402 was on an active proliferation by the treat ment of 5-Fu and DDP for half an hour, and the proliferation inhibited after 12 hours; but the proliferation was inhibited by 4-PA after half an hour of tr eatment. (2) The inhibitory rates increase with time and were over 50% after 48 ～72 hours of treatment. (3) There was temporarily active proliferation of Bel- 7402 cells in the early period of chemotherapy by 5-Fu and DDP. Conclusion Continuous chemotherapy is effectiv e for the inhibition of Bel-7402 cells proliferation.
